For the first time in Call of Duty history, you will be able to take a female soldier through the game’s campaign. Unlike previous COD games, Black Ops 3 will allow you to create your protagonist, and playing as a female soldier is an option. This makes a decent amount of sense considering many CoD protagonists are silent protagonists anyway.
Black Ops 3 ’s campaign will also allow for co-op play for up to four players. In theory, this could mean four female leads.
According to campaign director Jason Blundell, Treyarch took inspiration from Mass Effect in order to make a gender neutral script that didn’t have to be changed based on the main character of the story. Studio Head Mark Lamia also mentioned Alien as an inspiration, which was originally written for a male lead but ended up starring Sigourney Weaver.
Source: GamesRadar